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En forgiftning viser sig ofte umiddelbart ved kvalme og opkastninger. En leverskade viser sig derimod først efter nogle dage, med blandt andet påvirkning af hjernen.I slutningen af 1800-tallet fandt en tysk kemiker ud af, at virkningen skyldes stoffet acetylsalicylsyre. Det fik lægemiddelfirmaet Bayer til at udvikle Aspirin og senere Kodimagnyl,